Funding
NIH - 5R33AG069794
Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer's Disease Study (D-PRESCRIBE-AD)
Funder: National Institutes of Health
PI: Jerry Gurwitz, University of Massachussetts
Period of Performance: September 30, 2020 - August 31, 2025
Objectives
During the R33 phase we will sequentially implement two separate pragmatic trials, each enrolling over 11,000 patients, adapting the second trial based on the findings and experience gained in the first. The R33 aims are: (1) to assess the impact of the patient/caregiver educational intervention on inappropriate prescribing to AD/ADRD patients, employing a prospective, cluster randomized trial design with three arms; and (2) to create a plan for disseminating study findings to stakeholders who might implement the intervention or make decisions about its future use.
Supported Publications that Include Dr. Parlett
- Singh S , Li X , Cocoros NM et al . High-risk medications in persons living with dementia: a randomized clinical trial .Jama Intern Med. 2024; 184 (12) : 1426-33 . doi: 10.1001/jamainternmed.2024.5632 .
- Singh S , Cocoros NM , Li X et al . Developing a program to educate and sensitize caregivers to reduce the inappropriate prescription burden in the elderly with alzheimer's disease (d-prescribe-ad): trial protocol and rationale of an open-label pragmatic, prospective randomized controlled trial .Plos One. 2024; 19 (2) : e0297562 . doi: 10.1371/journal.pone.0297562 .
- Cocoros NM , Gurwitz J , Cziraky MJ et al . Pragmatic guidance for embedding pragmatic clinical trials in health plans: large simple trials aren't so simple .Clin Trials. 2023; 20 (4) : 416-24 . doi: 10.1177/17407745231160459 .